EBOO Therapy

Extracorporeal Blood Oxygenation and Ozonation (EBOO) therapy is an advanced medical
ozone treatment that involves drawing blood from a patient, enriching it with medical-grade
ozone and oxygen, and then returning it to the body. This extracorporeal process enables highvolume ozone delivery while simultaneously filtering the blood, making EBOO distinct from
other ozone therapies like major autohemotherapy (MAH). EBOO has gained popularity as a
systemic detoxification and immune-modulating therapy and is typically administered under the
supervision of integrative or functional medicine practitioners.

Mechanism and Process

During EBOO, blood is extracted through a venous line, passed through a dialysis-like filter
where it is exposed to a controlled mixture of oxygen and ozone gas, and then re-infused into the
body via another venous access. The ozone acts as a potent oxidative agent that stimulates the
production of antioxidants, modulates the immune system, and promotes oxygen metabolism.
The filtration process also removes inflammatory debris and lipid peroxides, contributing to the
therapy’s detoxifying effects [1][2].

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Conditions Treated

EBOO therapy is primarily used as an adjunctive treatment for chronic and systemic conditions
that involve inflammation, oxidative stress, and immune dysregulation. Commonly treated
conditions include:  Chronic Lyme disease and other tick-borne infections
 Autoimmune disorders such as lupus, rheumatoid arthritis, and multiple sclerosis
 Cardiovascular conditions including atherosclerosis
 Viral infections (e.g., hepatitis, long COVID)  Chronic fatigue syndrome and fibromyalgia
 Mold toxicity and environmental illness [3][4]
Patients often seek EBOO when conventional treatments have failed or as part of a
comprehensive integrative protocol.

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Safety and Considerations

EBOO is generally considered safe when administered by trained professionals, though it
requires venous access, sterile technique, and monitoring for oxidative stress. Potential side
effects are rare but can include vein irritation, transient fatigue, or Herxheimer reactions (a
temporary worsening of symptoms due to toxin release). It is contraindicated in individuals with
G6PD deficiency, hyperthyroidism, or active bleeding disorders [5].
Conclusion
EBOO therapy is a cutting-edge modality in integrative medicine that combines blood
oxygenation, ozone therapy, and filtration in a single session. Its ability to support detoxification,
enhance immune regulation, and improve oxygen utilization makes it a promising treatment for
various chronic and complex conditions, although more clinical research is needed to validate its
efficacy and establish standardized protocols.

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References:

1. Bocci, V. A. (2011). Ozone: A New Medical Drug. Springer. 2. Rowen, R. J., & Robins, H. (2019). A plausible “penny” costing effective treatment for coronavirus—ozone therapy. Journal of Infectious Diseases and Epidemiology, 5(3). 3. Tyacke, M., et al. (2022). The Use of Extracorporeal Ozone Therapy in the Treatment of Chronic Infections. Integrative Medicine: A Clinician's Journal, 21(4). 4. Jacobs, M. T. (2020). The Ozone Miracle: Medical Ozone Therapy. MindStream Publishing. 5. International Scientific Committee of Ozone Therapy (ISCO3). (2020). Guidelines for the Use of Ozone in Medicine. 3rd edition.